A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure ...

A new genetic screening method allows researchers to efficiently modulate individual genes across entire tissues and provides ...

If you've been to a museum about the history of medicine or surgery, you've probably seen loads of preserved human remains that have been used as teaching aids or in scientific research. Access to ...

Georgia Tech researchers demonstrated the mechanics behind neural tube closure, which can lead to severe or fatal birth defects if unsuccessful.

Neural tube morphogenesis is the process by which a flat sheet of neuroepithelial cells transforms into a closed tubular structure that gives rise to the brain and spinal cord. This transformation is ...

Anencephaly occurs when an infant is born without parts of their brain and skull. It is a severe congenital anomaly, which means that a baby develops anencephaly in the womb. Anencephaly is a ...

Analysis of U.S. survey data showed that two-thirds of reproductive age women had one or more modifiable risk factors for birth defects. Common risk factors included obesity, folate concentrations ...

In about one out of every 1,000 pregnancies, the neural tube, a key nervous system structure, fails to close properly. Georgia Tech physicists are now helping explain why this happens, having ...