Modern crop breeding is entering a new era of genome design, led by genome editing technologies as mainstream tools for targeted genome modification. In a review published in Nature Reviews Genetics, ...

An understanding of the origin and dynamics of heritable genetic variation within classical animal breeding programs is needed to provide the context for understanding the contributions and concerns ...

Genetic regulation of glucose homeostasis is central to the maintenance of human health and the prevention of metabolic disorders such as type 1 and type 2 diabetes. Recent advances in molecular ...

The prime editor is a fusion protein consisting of a catalytically impaired Cas9 nickase (Cas9n) and an engineered reverse transcriptase (RT). The Cas9n is guided by a prime editing guide RNA (pegRNA) ...

CRISPR-Cas9 is a powerful new tool for editing the genome. For researchers around the world, the CRISPR-Cas9 technique is an exciting innovation because it is faster and cheaper than previous methods.

CRISPR functions as a programmable genetic memory system derived from bacterial immune defenses against viral infections. Guide RNA allows for rapid multiplexed targeting compared to older ...

A team of Chinese researchers has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August ...

Genetic defects are exceedingly common, which is not surprising considering just how many cells make up our bodies, including our reproductive cells. While most of these defects have no or only minor ...

Researchers have determined whether a specific chemical modification of a protein that packages the genome called a histone affects gene activity and cell proliferation. Researchers have determined ...

The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...

A committee-supported project or activity that has been completed and for which output dissemination has begun. Its committee has been disbanded and closeout procedures are underway. An ad hoc ...